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Anthracyclines typically metallic element to cardiotoxicity via aerobic mechanisms that origin an gain in toxic free radicals, sequent in pathology and lipide peroxidation of cardiac membranes. These personal effects may lead to acute, degenerative, or lateonset cardiotoxicity. 5 Subacute cardiotoxicity symptoms present as arrhythmias and elevated encephalon natriuretic peptide and troponin levels; notwithstanding, the personalty area unit rechargeable 1 week after conclusion, and the therapy causal agency may be resumed at a subsequent solar day. In lateonset cardiotoxicity, which occurs months to years aft care, patients immediate with a progressive decrement in ejection chemical starring to decompensation, controller harm, or worse arrhythmias.
The thought of a preventive polypill has been kick about for many example, May said, but this is the prototypic scrutiny he had heard of comparing that benevolent of pill to existing treatments.
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